| 초록 |
Recovery of bone fractures is known to progress through various stages of bone regeneration. Ultrasound is known as a treatment device that can help restore bone fractures. In our previous study, injectable alginate (ALG)/hyaluronic acid (HA) hybrid hydrogels with time-dependent sol-gel transition showed the positive bone regeneration behavior. In this study, human bone marrow-derived mesenchymal stem cells (hMSC)-loaded hydrogels with different ALG/HA ratio (10/0, 9/1 and 8/2) were injected into the skull bone defect of SD rat, and were stimulated with pulsed ultrasound to investigate the effect of bone regeneration on the ultrasound stimulation. Bone regeneration behaviors were analyzed by micro-CT and Masson’s trichrome staining at 4, 8 weeks after surgery. Our results suggest that bone regeneration was high in the ALG/HA (8/2) group and was highly dependent by the applied ultrasound stimulation. |
