| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Photosensitizing polymer nanoparticles for cancer immunotherapy |
| 초록 |
In consequence of investigating the interaction of the immune system with the cancer cells, polymeric nanoparticles (NPs) in combination with photodynamic therapy (PDT) and immunotherapy appears to be a next generation therapeutic strategy that can eliminate primary tumors, inhibit metastases and prevent tumor relapses. Here, we devised combined method on the basis of polymeric nanoparticles with co-encapsulated photosensitizing agent and Toll-like-receptor-7 (TLR-7) targeting adjuvant. We next investigated cell toxicity of PDT treated cells and in vitro dendritic cells activation. As a result Western blot and flow cytometry data demonstrated that the presence of adjuvant triggered more intensive immune response. Further findings during in vivo tumor model experiments suggest that NPs can be applied for near-infrared (NIR) light-triggered PDT and cause ablation of primary tumors with following prevention of metastases. |
| 저자 |
Assel Seitkazina1, 정근수2, 김세훈3
|
| 소속 |
1Univ. of Science and Technology- Korea Institute of Science and Technology Campus, 2서울대, 3KIST |
| 키워드 |
polymer nanoparticle; photodynamic therapy; immunotherapy
|
| E-Mail |
|
