| 초록 |
Dyes have been widely utilized as a theranostic agent for biomedical applications due to their therapeutic efficacy on various diseases as well as photophysical properties. However, the practical use of dyes has been often limited by inherently poor targetability and stability under physiological environment. In this work, to utilize dyes as a theranostic agent, we devised dye-entrapped nanoparticles with high brain blood barrier (BBB)-permeability for treatment of traumatic brain injury (TBI). The nanoparticle was fabricated via physical nanoassembly of dye and inactive ingredients, to form a stable aqueous dispersion of tiny colloid. The BBB-permeability and brain delivery efficiency of the nanoparticles were evaluated by fluorescence imaging of a normal mouse upon systemic administration of the nanoparticles. Further, therapeutic efficacy was evaluated by histological analysis of brain tissues resected from TBI mouse model after administration of the nanoparticles. |
