| 학회 | 한국화학공학회 |
| 학술대회 | 2003년 가을 (10/24 ~ 10/25, 한양대학교) |
| 권호 | 9권 2호, p.1571 |
| 발표분야 | 고분자 |
| 제목 | Biomedical Applications of Self-Assembled Chitosan Nanoparticles |
| 초록 | Chitosan, the N-deacetylated derivative of chitin, has attracted significant interest in a broad range of scientific areas, including biomedical, agricultural, and environmental fields. However, the extended applications of chitosan in biomedical field are frequently limited because it is insoluble in biological solution (pH 7.4). Of chitosan derivatives, glycol chitosan is emerging as a novel carrier of drugs because of its solubility in water and biocompatibility. In this study, to obtain novel amphiphilic polymers that provide potential applications in biotechnology and medicine, hydrophobically modified glycol chitosans (HGCs) were prepared by covalent attachment of deoxycholic acid or 5β-cholanic acid to glycol chitosan through amide formation. The self-aggregation behavior and microscopic characterics of HGCs were investigated by using dynamic light scattering and fluorescence spectroscopy. The HGCs formed self-aggregates in an aqueous phase and their mean diameters were maintained over 15 days in a biological solution (pH 7.4) at 37℃, implying a potential for biomedical application. |
| 저자 | 권익찬1, 권승리1, 박재형1, 정혜선1, 김인산2, 정서영1 |
| 소속 | 1KIST, 2경북대 의대 |
| 키워드 | nanoparticle; self-assembly; chitosan; targeting delivery |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
