| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Identification of the biosynthetic gene cluster for the antituberculosis agents from marine-derived bacterial strain and production of new derivatives |
| 초록 |
The novel cyclic depsipeptides produced by marine bacterial strain belonging to the Streptomyces genus are potent antituberculosis agents. The peptides include unusual amino acid units, N-methyl-4-methoxytrytophan and β-hydroxyphenylalanine. Through genome sequencing, we have identified a 41.4-kb nonribosomal peptide synthetase (NRPS) gene for cyclic peptide core along with precursor biosynthesis and modification genes for tryptophan or phenylalanine moieties. Gene deletion and complementation allowed the confirmation of the biosynthesis and modification of the unusual amino acid moieties as well as the generation of new and potentially clinically significant derivatives. |
| 저자 |
김은지1, 오동찬2, 윤여준1
|
| 소속 |
1이화여자대, 2서울대 |
| 키워드 |
Marine natural product; Biosynthetic gene cluster; Antituberculosis agent
|
| E-Mail |
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