| 학회 |
한국재료학회 |
| 학술대회 |
2012년 봄 (05/17 ~ 05/18, 무주덕유산리조트) |
| 권호 |
18권 1호 |
| 발표분야 |
D. 바이오재료(Biomaterials) |
| 제목 |
DNA의 구조적, 기능적 특성과 이의 환경, 의료 분야에의 응용 |
| 초록 |
In the first part of this talk, I will introduce an effort to use gold nanoparticles and UO22+ (uranyl) specific DNAzyme for development of highly sensitive and selective colorimetric uranyl sensors. In addition, I will discuss how DNA aptamers can be delivered by nanoparticles to cancer cell nucleus and released by ultrafast femtosecond pulsed laser for targeted cancer therapy. Finally, I will show how proteins such as streptavidin and myoglobin, or nanoparticles can be precisely aligned on DNA with nanometer resolution via backbone-modified phosphorothioate DNA and bifunctional linkers. These interesting functional and structural properties of DNA can provide new opportunities to develop dynamic DNA structures for potential use as intracellular sensors and drug delivery agents. |
| 저자 |
이정헌1, Teri Odom2, Yi Lu3
|
| 소속 |
1성균관대, 2Northwestern Univ., 3Univ. of Illinois at Urbana-Champaign |
| 키워드 |
DNA; 압타머; DNAzyme; 나노파티클; 암진단; 암치료; 우라늄
|
| E-Mail |
|
