| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Development of safe and efficient lipid nanoparticles (LNP) including biodegradable ionizable lipid |
| 초록 | The development of vaccine has become a hot topic during thePandemic of SARS-COV-2. In particular, mRNA vaccines and lipid nanoparticlesthat deliver mRNA are actively under investigation. Lipid nanoparticle (LNP)technology has been widely used as a delivery platform to facilitate thedelivery of mRNA to target tissues or cells. However, the ionizable lipidsdeveloped in the early days had a toxicity issue due to its long half-life.Here, we have synthesized and developed an ionizable lipid (EZ4) containingbiodegradable functional groups to lower the toxicity. EZ4 showed a good transfectionefficiency to strongly express target protein compared to conventionalionizable lipids when injected through intravenously (IV) and/or intramuscularly(IM). Moreover, it showed low toxicity both in vitro and in vivo.EZ4 has shown great potential for the development of new generation ofbiodegradable ionizable lipids. |
| 저자 | 이예지, JEONG MICHAELA, 김민정, 이혁진 |
| 소속 | 이화여자대 |
| 키워드 | Lipid nanoparticle; mRNA; Ionizable lipid |
