| 학회 |
한국화학공학회 |
| 학술대회 |
2004년 봄 (04/23 ~ 04/24, 공주대학교) |
| 권호 |
10권 1호, p.467 |
| 발표분야 |
생물화공 |
| 제목 |
Formation of water-soluble inclusion complex powder using SAS process |
| 초록 |
Itraconazole is a drug used in the treatment of fungal infections and has a highly lipophilic property. In this study inclusion complex of itraconazol/HP-β-CD was prepared using a supercritical antisolvent (SAS) process. Various process parameters such as temperature, pressure, concentration and flow rate were investigated. From the in vitro test, the solubility and dissolution rate of itraconazole/HP-β-CyD inclusion complex were significantly increased compare to that of untreated itraconazole. The present results suggest that the SAS process is a promising method for the preparation of water-soluble cyclodextrin inclusion complex of water-insoluble drugs. |
| 저자 |
김정규1, 이상윤2, 최효진1, 김우식2, 유종훈1, 임교빈1
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| 소속 |
1수원대 화공생명공학과, 2연세대 화학공학과 |
| 키워드 |
SAS; inclusion complex; itraconazol
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| E-Mail |
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| 원문파일 |
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