| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Modulation of drug release pattern and bone tissue regeneration of chitosan microspheres mediated by polyvinylpyrrolidone |
| 초록 |
Chitosan (CHN) is a biodegradable natural polymer which has excellent biocompatibility. It has been widely used as bone tissue substitute grafts. Usage of CHN microsphere has various advantages to be used as biomaterials and drug delivery carrier. Hyaluronic acid (HA) is polysaccharide found rich where cell proliferation is actively taking place. Combination of HA with CHN can be possibly improve the biological properties, biocompatibility and biodegradation, in particular. This study investigated the modulation of CHN microsphere using a synthetic organic component enabling controlled drug release. The physicochemical properties of the fabricated modified CHN microspheres were analyzed using SEM and zeta potential. Their chemical state was evaluated by FTIR. Biodegradation pattern and drug release were analyzed by weight reduction measurement and HPLC analysis. Cytotoxicity of the microspheres was examined via cell assays using osteoblastic MG63 cells. |
| 저자 |
김정헌, 박선호, 이상헌, 임예람, 이우걸
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| 소속 |
단국대 |
| 키워드 |
Key Words: Polyvinylpyrrolidone; PVP; Chitosan; Hyaluronic acid; microspheres
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| E-Mail |
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