| 초록 |
Injectable hydrogels have been widely utilized as therapeutic implants and vehicles of drugs, proteins and cells for therapeutic applications, as they have several advantages based on minimally invasive injection procedure. In our group, various types of in situ forming hydrogels have been developed as injectable and sprayable bioactive matrices. The hydrogel matrices were made of various synthetic and natural polymers, including PEO-PPO copolymers (e.g. Tetronic and Pluronic), gelatin, hyaluronic acid, chitosan, and heparin. These polymers were functionalized with phenol-derivatives, which can be cross-linked in situ to form the hydrogels via enzyme-mediated reaction using horseradish peroxidase, or glucose oxidase, etc under physiological conditions, and the physico-chemical properties of the gel matrices could be controlled by varying material parameters. These in situ gelling systems have been extensively evaluated using various peptides, proteins, and cell types as well as in vivo animal models. In this presentation, tissue regeneration, stem cell engineering and drug delivery will be reported using our gelatin based injectable and sprayable hydrogels. |
