| 학회 | 한국공업화학회 |
| 학술대회 | 2014년 봄 (04/30 ~ 05/02, 제주국제컨벤션센터) |
| 권호 | 18권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Stem cell painting using adhesive hydrogel for the treatment of atherosclerosis |
| 초록 | We developed an adhesive hydrogel based on catechol-modified hyaluronic acid (HA-CA) for stem cell transplantation to treat atherosclerosis. In a rabbit model of atherosclerosis, the HA-CA hydrogels containing mesenchymal stem cells (MSCs) were painted onto the outside surface of arterial blood vessels. The treatment using HA-CA hydrogel with MSCs reduced the thickness of neointima and improved reendothelialization on the injured vessels. The treatment also reduced macrophage-positive area and the expression of inflammation biomarkers in the plaques. Therefore, this adhesive HA-CA hydrogel can provide an efficient strategy to deliver stem cells for treating atherosclerosis. Acknowledgments: This work was supported by a grant (HI11C0522) from the Korea Health Technology R&D Project funded by the Ministry of Health and Welfare and a NRF grant (2010-0020409), Republic of Korea. |
| 저자 | 신지수1, 이정승1, 김애경2, 김동익2, 조승우1 |
| 소속 | 1연세대, 2성균관대 |
| 키워드 | adhesive hydrogel; stem cell transplantation; atherosclerosis |
