| 초록 |
Peptoids are a unique class of peptidomimetics based on oligo-N-substituted glycine scaffolding. As a bioinspired material, the properties of peptoids lie in-between natural biopolymers and non-natural synthetic polymers. Like biopolymers, they are information-rich polymers, offering precise control of main chain length, side chain functionality, and monomer sequence. The structural similarity to polypeptides has been responsible for the impressive diversity of conformation and biological activity observed for peptoids; however, non-natural N-substituents render them higher stability than that of natural counterpart (i.e., protease-stable). Using the unique structural properties, the peptoid are actively investigated to mimic natural peptides and proteins such as antimicrobials and subcellular organelle targeting vehicles. Our ongoing efforts to develop highly efficient and selective antimicrobial peptoids and cell-penetrating peptoids will be presented. |
