| 초록 |
Scaffolds with hierarchical pore system have been studied on diverse fields such as separations, and tissue engineering because hierarchical porosity improves material properties such as mechanical properties, transport properties, and molecule selectivity. Here, we introduce a new approach to fabricate hierarchical macroporus and mesoporous silica scaffold. This method is composed of two steps; 1) compacting mesoporous silica, the building blocks of the scaffold, and sodium chloride, sacrificial macropore porogen, into a designated shape, 2) leaching out the sodium chloride to generate macropores. The mechanical strength of the resulting inorganic 3D scaffold was significantly improved by controlling the interfaces of mesoporous silica particles, which allowed for high structural stability during in vivo implantation. The scaffolds loaded with pro-inflammatory cytokine were implanted into the mice and recruited high number of host immune cells into the macropores, which shows their potential use for immunomodulation. |
