| 초록 |
Chemodynamic therapy (CDT) has emerged as a promising cancer treatment strategy through its ability to generate hydroxyl radicals (∙OH) at tumor sites for inducing apoptosis. Attaining high Fenton catalytic efficiency at low doses is a critical issue for clinical application of CDT. However, it should be noted that promoting the tumor-selective Fenton activity rather than simply enhancing the overall Fenton reactivity is highly demanded to prevent the adverse effects on normal cells. Herein, tumor microenvironment (TME)-mediated synergistic Fenton reaction is achieved by copper-iron peroxide nanoparticles (CFp NPs). Cu and Fe ions, released in response to weakly acidic TME, form a Cu-Fe catalytic loop and cooperatively promote ∙OH generation in highly reduced states. The synergistic effect resulting from the Cu+-assisted conversion of Fe3+ to Fe2+ provides a unique feature that differs from previous heterogeneous CDT systems in which the two metals act independently. The CFp NPs exhibit outstanding anti-tumor therapeutic efficacy in vivo with additional functions: hypoxia relief, TME-responsive T1 magnetic resonance imaging contrast effect, and H2O2 self-supplying. |
