| 초록 |
Blood-compatible biomaterials have been of importance for a variety of cardiovascular medical applications. In this study, we have tested a Nitinol-Au whose surface was grafted with zwitterionic PEG, with the aim of development of peripheral arterial stent. Poly(ethylene glycol) (PEG) is blood-compatible and sulfobetaine (-N+-SO3-), a well-known class of zwitterionic polymer is biocompatible. Gold-coated Nitinol (Nitinol-Au) was chemisorbed through the thiol group (-SH) by L-cysteine, cysteamine, and 3-mercaptopropionic acid (MPA), the zwitterionic PEG (PEG-N+-SO3-) was grafted onto the chemisorbed Nitinol-Au. The modified Nitinol-Au surfaces were characterized ESCA, SEM, ATR-FTIR, and water contact angle measurement. The blood compatibility was also evaluated using plasma protein adsorption and platelet adhesion tests. The modified Nitinol-Au surfaces were further characterized by enzyme-linked immunosorbent (ELISA) assay, and activated partial thromboplastin time (APTT) assay. |
