| 초록 |
A series of protein- and bacterial-resistant hydrogels was prepared via surface-functionalization of p(HEMA)-based hydrogel lenses with biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) p(MPC). The prepared hydrogels showed an improvement on the surface wettability while maintaining good transmittance of over 90% and retaining water content of over 60%. The presence of zwitterionic surfaces has rendered the anti-biofouling nature of the prepared hydrogels. The lysozyme and bovine serum albumin (BSA) adsorption to the hydrogels were significantly lowered (73-74% and 59-66%, respectively) than that of the unmodified hydrogels. Overall, the results presented offer a general approach in developing biomaterials with remarkable combinations of properties such as excellent transmittance, highly hydrophilic surfaces, and improved protein and bacterial deposition resistance |
