| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Antioxidant biodegradable polymer nanoparticles for the treatment of airway inflammatory diseases |
| 초록 |
Hydroxybenzyl alcohol(HBA) is one of phenolic compounds in herbal agents and plays a pivotal role in protection against oxidative damage-related diseases due to anti-inflammatory effects. We have developed a new biodegradable antioxidant copolyoxalate(HPOX), in which HBA is chemically incorporated into its backbone based on the hypothesis that peroxalate ester linkages in the backbone reacts with and scavenges hydrogen peroxide, leading the release of HBA. HPOX could be dispersed into a single emulsion for the formulation of nanoparticles which had a mean size ~500nm in diameter. The polymer nanoparticles showed antioxidant activity by suppressing the production of hydrogen peroxide and nitric oxide. The in vivo studies using a asthma murine model showed that HPOX nanoparticles exerted antioxidant and anti-inflammatory activities by reducing the recruiment of eosinophils. This study implies that the HPOX nanoparticles is a promising treatment of airway inflammatory diseases. |
| 저자 |
국경혜, 유동혁, 박승규, 이은선, 강길선, 이동원
|
| 소속 |
전북대 |
| 키워드 |
Antioxidant; Anti-inflammatory; Nanoparticles; Asthma
|
| E-Mail |
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