| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Evaluation of Bone Regenerative Potential in Critical Size Defect by Demeneralized Bone Matrix |
| 초록 | Bone grafts are frequently used in the treatment of bone defects. Bone harvesting can cause postoperative complications and sometimes does not provide a sufficient quantity of bone. Therefore, allo-bone and synthetic biomaterials have been investigated as an alternative to autogenous bone grafts. Allogenic demineralized bone matrix(DBM) is widely used as a bone graft substitute in orthopedics and dentistry. It has been used successfully to regenerate bone, but has different osteoinductive potential by different processing methods. The objective of this study was to evaluate the repair of critical size bone defects(CSD) by DBM prepared through an advanced processing procedures. Therefore, this study describe the preparation and characterization of DBM. The prepared DBM were characterized by in vitro alkaline phosphatase assay(ALP) using C2C12 myoblast cell line and also investigated in vivo animal test. On animal test, 8.0mm diameter full-thickness bone defect was made in the skulls of rats and each defect was either left empty(control defects) or filled with the DBM. The rats were sacrificed 2, 4, 8, and 12 weeks after surgery and tissue samples were analyzed by radiography and histology. |
| 저자 | 송석범1, 김진영1, 서석진1, 김태운1, 강계원1, 김진2, 이광원3 |
| 소속 | 1한스바이오메드, 2가톨릭의대 대전성모병원 구강외과학교실, 3을지의대 정형외과학교실 |
| 키워드 | demineralized bone matrix; critical size defect |
