| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Surface-decoration of hydrolyzed PCL nanofibrils with photo-crosslinakble gelatin for 3D cell skin model |
| 초록 |
We prepared gelatin hydrogel coated on the surfaces of the PCL nanofibrils for 3D cell cultivation. Methacrylate functionalized gelatin (gelMA) that gelMA was adsorbed on the surfaces of hPCL by a dipping method. The gelMA incorporated nanofibrils was photo crosslinked by photo-initiator and UV light. gelMA was more efficient coated on hPCL than gelatin and the water swelling ratio of gelMA@hPCL was much higher than gelatin@hPCL and hPCL. gelMA@hPCL also showed superior biocompatibility to conventional nanofibrils. Human dermal fibroblast cells were cultured with gelMA@hPCL, gelatin@hPCL and hPCL for 14 days. Cells cultivated with gelMA@hPCL showed higher proliferation, and formed better cell/nanofibrils complex compared with other nanofibrils. Thus, gelMA@hPCL hybrid matrix are expected materials with distinct characteristics of both hydrogels and nanofibrils for 3D cell cultivation. |
| 저자 |
유혁상, 강면구, 신지운, 이솔, 모미, 손영주
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| 소속 |
강원대 |
| 키워드 |
electrospinning; nanofibril; gelatin; skin
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| E-Mail |
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