| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Poly(N-vinyl caprolactam) hydrogel microparticle for controlled thermos-responsive drug release |
| 초록 |
For the realization of therapeutic efficacy, controlled drug delivery system is important. Here, we introduce Poly(N-vinyl caprolactam) (PVCL) microparticles for temperature-responsive drug delivery. PVCL-based microparticles were synthesized via Stop Flow Lithography (SFL) process. Polymer network in microparticles are contracted above certain temperature known as lower critical solution temperature (LCST) behavior. After setting the LCST close to body temperature by adding hydrophilic component, we conducted the drug release test using doxorubicin as a model drug. As a result, we revealed that the releasing rates of doxorubicin were significantly higher at above LCST. Using SFL, we fabricated multicompartmental PVCL microparticles and showed that more than two modes of drug release profile can be accomplished. Also, we carried out in vitro experiments and clarified the significantly increased anticancer activity according to the temperature difference. |
| 저자 |
이낙준1, 노윤호1, 김현웅1, 홍은지2, 심민석2, 봉기완1
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| 소속 |
1고려대, 2인천대 |
| 키워드 |
PVCL; SFL; microparticle; drug delivery
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| E-Mail |
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