| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparation of Mesoporous Silicas Modified with Aromatic functionalities for pH-Responsive Drug Delivery |
| 초록 |
Well-ordered mesoporous silica material was prepared by sol-gel approach by using cetyltrimethylammonium bromide (CTAB) as surfactant and tetraethyl orthosilicate (TEOS) as silica precursor under basic condition. Prior to the surfactant extraction, the outer surface of the silica materials were modified with 3-Chloropropyl triethoxysilane (ClPTES) and further modified with aromatic functional groups which is desirable to form multiple hydrogen bonding interactions along with the modified aromatic groups that works as cap molecule. The resulted materials were used for cargo loading after surfactant extraction and characterizations. The cargo loading/release efficiency was performed at different pH conditions by changing the pH of the release medium. All the obtained results showed that the prepared mesoporous silica drug carrier is suitable for pH-responsive target drug delivery in cancer therapy. |
| 저자 |
산타 무티, 하창식
|
| 소속 |
부산대 |
| 키워드 |
mesoporous silica; surface modification; drug delivery; pH responsive; cancer therapy
|
| E-Mail |
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