| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
휴먼인터페이스 의료용 고분자재료 (의료용 고분자 부문위원회) |
| 제목 |
Oxidative stress regulating engineered polymers for the treatment of cancer and inflammatory diseases |
| 초록 |
Reactive oxygen species (ROS) are a group of highly reactive small molecules generated by all aerobic organisms. The high level of ROS causes cellular damage and apoptotic cell death, depending on their concentration and induces inflammation diseases. Compared to normal cells, cancer cells are under oxidative stress associated with increased ROS production due to disrupted ROS homeostasis and utilize ROS to drive proliferation. Ironically, cancer cells have also adapted to oxidative stress by activating antioxidant systems. Therefore, cancer cells are susceptible to ROS insults induced by exogenous agents that weaken antioxidant defense or augment ROS generation to a level above which cells cannot survive. In this presentation, novel antioxidant and antioxidant polymeric prodrugs are discussed with emphases of rational design and proof-of-concept studies in animal models. |
| 저자 |
이동원 |
| 소속 |
전북대 |
| 키워드 |
cancer; oxidative stress; polymer; prodrug; inflammation
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| E-Mail |
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