| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
콜로이드계면화학_포스터 |
| 제목 |
Photodynamically Controlled Delivery of Anticancer Therapeutics Using Folate-PEG-PPADT Block Copolymer Micelles |
| 초록 |
The presence of a high concentration of reactive oxygen species (ROS) is an important biomarker of cancers. Poly(1,4-phenyleneacetone dimethylene thioketal) (PPADT) was introduced for oral delivery of siRNA to ROS-rich inflammation sites in the intestine. In this work, we fabricated ROS-sensitive polymer micelles using an amphiphilic block copolymer of poly(ethylene glycol) and PPADT for light-activated anticancer therapy. The ROS-sensitive polymeric micelles, which coencapsulate photosensitizers and paclitaxel, degraded upon light illumination for controlled burst release of paclitaxel to the tumour cells. The targeting efficacy of the polymer micelles for HeLa cells increased through the introduction of folic acid on the surface of the polymer micelles, efficiently causing cytotoxicitiy to HeLa cells at a low concentration of paclitaxel in vitro and in vivo. Acknowledgement: Basic Science Research Program (NRF-2013R1A1A1009626). |
| 저자 |
Geok Leng Seah1, 남윤성2
|
| 소속 |
1KAIST, 2KAIST / KAIST Institutes for Nanocentury and Health Science and Technology |
| 키워드 |
ROS; anticancer; light; amphiphilic block copolymer; photosensitizer
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| E-Mail |
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