| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Enhanced airway inflammatory diseases therapy using porous antioxidant microparticles. |
| 초록 |
Inhaling anti-inflammatory drugs are used as treatment for asthma. Most steroidal drugs have effectiveness to asthma but causes adverse side effects. Therefore, steroidal drugs administration needs pulmonary drug delivery systems. The biodegradable polymer (PVAX) was developed for scavenge hydrogen peroxide and synergetic antioxidantion and anti-inflammatory effect. In this work, we find the potential of dexamethasone (DEX) loaded porous PVAX microparticles as a therapeutic system for asthma. DEX-loaded porous PVAX microparticels reduced oxidative stress and expression pro-inflammatory tumor necrosis factor-alpha, inducible nitric oxide synthase and showed significantly enhanced therapeutic effects in the lung of ovalbumin asthmatic mice models. Their excellent biocompatibility and intrinsic antioxidant and anti-inflammatory activity, PVAX microparticles hold excellent potential as therapeutic systems for the treatment of airway inflammatory diseases. |
| 저자 |
이동원, 동메이우, 유동혁, 정은경, 강창선, 정다희
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| 소속 |
전북대 |
| 키워드 |
antioxidant; biodegradable polymer; airway inflammation; particles; hydrogen peroxide
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| E-Mail |
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