| 초록 |
An essential genetic principle is association, dissociation, and strand exchange of nucleic acid hybrids. Since free nucleic acids are highly flexible macromolecules, the possibilities of finding several different regions complementary to a given extent of single polynucleotide chains is quite high and will increase as the chain length increases. To overcome these folding problems, nucleic acid chaperones catalyze the folding of nucleic acids into the most stable conformations by reducing the energy barrier associating with dissociation and reassociation of nucleic acid base pairs in living system. Thus, an artificial agent that is capable of manipulating nucleic acid hybridization would be beneficial in the field of nanobiotechnology based on nucleic acid. In this study, it was demonstrated that cationic comb-type copolymers exhibiting nucleic acid chaperone-like activity may open a novel strategy for nanobiotechnology, such as DNA nanotechnology, genetic diagnosis, and gene delivery. The activity also could be regulated by modifying polymer structure. |
