| 초록 |
Rheumatoid arthritis (RA) is a complex chronic inflammatory disease affecting up to 1% of the population. Although the accurate cause of RA remains unknown, the activated macrophages are regarded as main cells which contribute to articular inflammation and pathogenesis of joint damage of RA. Consequently targeting activated macrophages has been considered as a powerful way of RA therapy. In this study, we prepared self-assembled dextran sulfate nanoparticles (DSNPs) for targeted therapy of RA. The physicochemical properties of DSNPs were characterized using various instruments. The therapeutic effects of the DSNPs were evaluated by measuring clinical scores. Overall, it was evident that the DSNPs have a great potential as a therapeutic agent for RA therapy. |
