| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.357 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Controlled Protein Delivery Based on Biodegradable Thermo-Sensitive MPEG-PCL Diblock Copolymer Hydrogels |
| 초록 | As a number of therapeutic protein drugs became available, the development of suitable protein drug release systems using biocompatible and biodegradable polymers has been focused on various biomedical applications.1 Recently, biodegradable thermo-sensitive hydrogels has many special characters such as good solubility in water, easy drug loading, non-toxicity, and biodegradability. Recently PEG-based diblock and triblock polyester copolymers were studied as injectable drug delivery system via stimulating to temperature.2 To prepare thermo-sensitive sol-gel polymers, we synthesized the diblock copolymer consisting of methoxy polyethylene glycol (MPEG, Mn=750 g/mole) and ε-caprolactone (ε-CL) by ring opening polymerization in the presence of HCl․Et2O at room temperature. (Table 1) The aqueous solution of MPEG-PCL diblock copolymers changed from sol to gel phase as the temperature increased. (Figure 1) Also, we fabricated 20 wt% PBS solutions loading 0.1 % bovine serum albumin, dextran, and insulin for investigating protein release behavior. (Figure 2) In conclusion, the aqueous solution of MPEG-PCL diblock copolymers exhibited the controlled release profiles of BSA, Dextran, and Insulin according as polymer concentration and drug loading amounts. Reference 1. S. D. Putney and P. A. Burke, Nature Biotechnology, 16, 153 (1998). 2. J. Y. Kim, S. Choi, J. J. Koh, M. Lee, K. S. Ko, and S. W. Kim, Pharmaceutical Research, 18, 548, (2001). |
| 저자 | 서광수1, 현훈1, 이창신2, 김문석3, 조선행3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2한남대, 3한국화학(연) |
| 키워드 | sol-gel; MPEG-PCL; protein delivery |
