| 초록 |
To reduce tissue or tumor ingrowth, covered metal stents have been developed. The effectiveness of covered metal stents may be attenuated by sludge or stone formation, or stent clogging due to formation of biofilm on the covering membrane. In this study, we tested the hypothesis that a covered metal stent containing silver particles (Ag-P) would prevent sludge and biofilm formation on the covering membrane. The Ag-P-integrated covered metal stent also resulted in significantly less stent-induced inflammation than a conventional covered metal stent. Therefore, the Ag-P-integrated covered metal stent reduced sludge and biofilm formation, and stent-induced pathological changes in tissue. Furthermore, the stent had a durable antibacterial effect, and there was no isolation from covered membrane to systemic absorption in vitro and in vivo. |
