| 학회 |
한국공업화학회 |
| 학술대회 |
2010년 가을 (10/27 ~ 10/29, 대전컨벤션센터) |
| 권호 |
14권 2호 |
| 발표분야 |
Bio-active, functional macromolecules and nanomaterials |
| 제목 |
Calcium Phosphate Mineralization on Self-Assembled Nanoparticles:A New Platform Technology for Nanomedicine |
| 초록 |
We report on the broad utilities of mineralized polymer nanoparticles in nanomedicine. As one example for cancer chemotherapy, the polymer nanocarrier with a calcium phosphate (Cap) mineral shell was developed by CaP deposition on a core-shell-corona polymer micelle. The CaP shell could minimize the loss of the entrapped doxorubicin (DOX) before reaching target tissues, and selectively dissolve in lower pH and Ca2+ concentration of endosomal compartments to facilitate intracellular DOX release. The mineralized nanocarriers showed the prolonged circulation time in blood and enhanced tumor specificity in tumor-bearing mice. |
| 저자 |
이상천 |
| 소속 |
경희대 |
| 키워드 |
Calcium phosphate; mineralization; polymer micelle; endosome
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| E-Mail |
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