| 초록 |
Benzylation and phthaloylation of β-chitosan are a particularly important precursor in view of conducting modification reactions regioselectively in organic solvents. In the benzylation and phthaloylation, however, the hydroxy groups of pyranose ring of chitosan are also substituted to some extent. If N-benzylation-chitosan can be prepared in a one step reaction, it would be very beneficial for expanding the scope of modification reaction to construct well-defined molecular architectures on chitosan. also, deprotection is very easiable of it. The objective of this work is to synthesize of amino acid bearing N1-chitosan as a water soluble chitosan derivative with enhanced antimicrobial activity by method of chemoselective N-phthaloylation and benzylation of β-chitosan and some modification reaction of N-benzylation-chitosan such as tritylation and tosylation. |
