| 초록 |
Retinoids are natural and synthetic analogues of vitamin A that are involved in the regulation of several biological function such as cellular differentiation. All-trans-retinoic acid(atRA), a hydrophobic anti-cancer drug, plays important roles in the regulation of proliferation and differentiation of epithelial tissues such as skin, bladder, lung, oral cavity, and mammary gland. However, atRA is rapidly metabolized to inactive polar metabolites such all-trans-4-oxo-retinoic acid. In this study, we aimed to synthesis of RA derivative coupled to water-soluble chitosan of RA-phosphate chitosan to afford atRA-phosphate CTS as antibacterial agents. And its were investigates their activity and it's spectrum. |
