| 초록 |
Hyaluronic acid (HA) is a non-sulfated glycosaminoglycan organic polymer , found as structural component of the extracellular matrix (ECM) in mammalian bone marrow and loose connective tissues of our body.Hyaluronic acid also play a major role in cell proliferation, motility, cell adhesion and gene expression .Cellular HA receptors such as CD44+ and RHAMM are overexpressed in cancer which makes it a good candidate for tumor targeting purpose.Here we have developed a T1 gadolinium contrast agent based on Hyaluronic acid (HA) that target CD44+ receptor over expression in cirrhosis which also display higher relaxation property than Primovist and better Contrast–to–Noise Ratio(CNR) at 20 min and even at 2 hr time period.And finally , hyaluronic acid micelle that can encapsulate hydrophobic anti-cancer drug such as Paclitaxel that specifically target CD44+ overexpressing tumor are synthesised which can act as promising drug delivery vehicle . |
