| 초록 |
Non-viral delivery systems for gene therapy have been increasingly proposed as an alternative to viral vector with safety and stability in storage, including synthetic cationic polymer such as poly(L-lysine) (PLL), polyethylenimine (PEI), and cationic lipid. However, the induced cytotoxicity and non-biodegradability of these cationic polymeric vectors along with the lack of efficient site-specific delivery systems impede the prevalent practical realization of gene therapy. Therefore, in our quest to develop a highly coveted vector which could provide all these attributes, we have devised various highly efficient vector systems having various properties such as reducibility, biodegradability, cell-specific targeting and low cytotoxicity. Here, we present the synthesis and characterization of polymeric gene carriers, in vitro and in vivo gene expression study, and targeting efficiency of ligand-containing polymeric vectors. |
