| 초록 |
While the systemic delivery of nanoparticles is a well-known strategy for the treatment of diseases, this method possesses limited therapeutic efficiency due to its low targeting efficacy and fast clearance. We suggest a concept for an injectable nanoparticle-hydrogel-nanoparticle system that overcomes these limitations by providing localized, long-term drug delivery. Notably, the amphiphilic polyphosphazene 1) demonstrated nano-sized micelle formation in aqueous solutions at low temperatures, 2) transformed into a gel state at body temperature through increased hydrophobic interaction, and 3) released the nano-sized micelles in its hydrogel state over a long-term period. This system, which aims to produce enhanced therapeutic effects through a local-site single injection and increased targeting efficiency over intravenous injections through the sustained release of nanoparticles, is here applied to deliver genes, chemicals, and cells to treat cancers and induce tissue regeneration. |
