| 초록 |
Biodegradable thermogel undergoes solution-to-gel transition by changing temperature. We have been searching for new polymeric thermogels and investigating gelation mechanisms and biomedical applications to drug delivery, 3D cell culture, and tissue engineering. PLGA, PCL, Pluronic derivatives, and polypeptide-based thermogels have been developed in the course of solving the problems of the thermogels such as short gel duration, sticky morphology, long reconstitution time, and storage stability. In particular, polypeptide thermogels exhibit stability under in vitro conditions, and degradation occurs under in vivo conditions. Neutral pH is maintained during degradation. In this presentation, we will summarize the development of thermogelling materials from the historical point of view and introduce the recent biomedical applications of the thermogels. |
