| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
[연구윤리위원회] 과학자의 책임과 의무 ; COVID-19 이후 대기 중 미생물 유래 유해인자 관리 기술 |
| 제목 |
High-throughput single-molecule bioassay platform using single-point functionalized carbon-nanotube field-effect transistor arrays |
| 초록 |
Nanoscale field-effect transistor (FET) for biosensing has been emerged to a portable, manufacturable, and scalable bioassay platform. Despite the rapid progress on the fabrication of carbon nanotube FETs and in the manufacturing facilities, a critical challenge in bio-functionalization of the nanomaterials has been a major barrier to expand this technology to commercial biosensor application. Here, we show an advanced single-point functionalization chemistry that is electrically controllable at single reaction level and applicable to many devices in parallel in arrays. This single-molecule field-effect transistor (smFET) arrays are chemically identified by attaching single-stranded complementary DNA encoding DNA hybridization, an aptamer probe encoding small-molecule bindings such as neurotransmitters and bioaerosol toxins. This platform allows to monitor the single-molecule binding kinetics and temporally analyze the target concentration changes. |
| 저자 |
이윤희 |
| 소속 |
DGIST |
| 키워드 |
carbon nanotube; smFET; single-point defect; DNA; aptamer; single-molecule kinetics
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| E-Mail |
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