| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Biomimetic and Anti-Inflammatory PLGA/ECM/MG(OH)2 Scaffolds for Kidney Tissue Regeneration |
| 초록 |
Biodegradable scaffolds to help repairing an injured tissue have been developed as a promising approach in the area of renal regeneration. In this study, decellularized renal extracellular matrix (ECM) and magnesium hydroxide (Mg(OH)2) were employed to improve tissue regeneration and biocompatibility of PLGA scaffold, respectively. In the pH measurement during degradation, the pH of pristine PLGA scaffolds decreased to 2.7, whereas the PLGA/ECM/Mg(OH)2 composites were maintained around pH 7. The PLGA/Mg(OH)2 scaffold containing 10% of ECM exhibited excellent cell proliferation as compared to PLGAscaffold. In following in vivo study, PLGA/ECM/Mg(OH)2 scaffolds showed successful reconstruction of glomerulus and very low inflammatory response. PLGA scaffolds containing decellularized matrix and Mg(OH)2 could be one of promising materials for regenerative treatment of renal diseases. |
| 저자 |
김윤아1, 이유진1, 전소영2, 권태균2, 고원건3, 정윤기1
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| 소속 |
1한국과학기술(연), 2경북대, 3연세대 |
| 키워드 |
decellularized ECM; magnesium hydroxidem; scaffold
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| E-Mail |
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