| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Regulation of hMSC behaviors on the dual-functional nanofibrous meshes for tissue engineering |
| 초록 |
Poly(L-lactide-co-ε-caprolactone) (PLCL) has been used to prepare the nanofibrous meshes for tissue engineering, which can play a role as an artificial extracelluar matrix(ECM) in regulating cell behaviors. However, hydrophobicity of the PLCL nanofibrous meshes has limited the proper interaction between the materials and cells exhibiting immature adherent morphology and reduced proliferation. To overcome the limitation, we used γ-ray irradiation to graft acrylic acid on the nanofibrous meshes, and a surface morphology and chemical property of the functionalized nanofibrous meshes were analyzed with SEM, ATR-FTIR, and water contact angle. Moreover, Gelatin and EGF as functional proteins in regulating the cellular responses were immobilized on the PLCL scaffolds. The adhesion and proliferation of the cells were significantly up-regulated on the dual-functional nanofibrous meshes. Therefore, our novel nanofibrous meshes can be used as alternative scaffolds in tissue engineering. |
| 저자 |
임종영1, 신영민1, 권희정1, 박종석1, 노영창1, 정성인1, 조선영1, 최종배1, 박은지1, 신흥수2, 임윤묵1
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| 소속 |
1한국원자력(연), 2한양대 |
| 키워드 |
tissue engineering; dual-functional; EGF; Gelatin; hMSC
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| E-Mail |
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