| 초록 |
Biodegradable poly(lactide-co-glycolide) (PLGA) with sirolimus (SRL) was coated on stainless steel (SUS 316L) spring by ultrasonic spray method. The molecular interaction among PLGA, organic solvent, and SRL affected surface roughness, particle size, and loading amount of SRL during coating process. As organic solvents influenced the conformational arrangement of polymer chain and the SRL aggregation, glass transition temperature (Tg) of PLGA matrix became significantly low due to plasticizer effect. The release pattern depended on the size of aggregated particle as a result of in vitro drug release. This study would have great potential for biomedical and pharmaceutical applications for controlled drug release including drug-eluting stent (DES). |
