| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Osteogenic Differentiation of Human Adipose-Derived Stem Cells on Titanium Surface with BMP-2-loaded Adhesive Nanoparticles |
| 초록 |
Herein, we report on the surface functionalization of titanium with adhesive nanoparticles (catechol-functionalized polyaspartate-b-polyphenylalanine micelles) for controlled incorporation and the release of BMP-2. BMP-2 was loaded onto the anionic polymer nanoparticles immobilized on the Ti surface by the electrostatic interaction. The sustain release of BMP-2 could be controlled by the adjusting the feed amount of BMP-2. To determine the osseogenetic effect, cellular attachment and proliferation, alkaline phosphatase (ALP) activity and calcium mineral deposition were assessed. The Ti-adhesive nanoparticle may find many utilities as a surface releasing system for medical devices including stents and dental implants. |
| 저자 |
이홍재, 구안나, 이상천
|
| 소속 |
경희대 |
| 키워드 |
adhesive nanoparticles; BMP-2; osteogenic differentiation
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| E-Mail |
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