| 초록 |
The advent of new controlled release systems has been demanded over the past decade to overcome the instability of therapeutic agents in physiological condition. Hydrogels, often formed by chemical reactions, have been recognized as a promising delivery carrier to improve the bioavailability of drugs by offering various advantages such as acceptable biocompatibility and less toxicity. Here we report a novel hydrogen bonding-mediated physical hydrogeling system. Galactaric acid, a natural monosaccharide diacid containing four hydroxyl groups, was polymerized with oligo-ethylene oxide diamines, to produce hydroxyl-rich polyamides capable of interchain hydrogen bonding. The polymeric hydrogen bonding behaviors in aqueous milieu were examined by changing the repeating unit of diamine monomer. Further, nano-sized hydrogelation was studied for widening the application area of hydrogels. |
