| 초록 |
Development of a rationally designed drug delivery strategy for effective anticancer therapy has been challenging. Herein, we report on a novel nano-assembly prepared by the inclusion complexes between a polymer-cyclodextrin (pCD) conjugate and a polymer-paclitaxel (pPTX) conjugate where the CD and PTX are separately conjugated to each poly(maleic anhydride) via ester linkages. The pCD::pPTX nano-assembly not only shows good water dispersibility due to the hydrophilic polymeric surface with carboxylate ions but also exhibits high stability in the blood due to the strong multivalent host–guest interactions. The nano-assembly is efficiently delivered into the targeted cancer cells via passive and active targeting mechanisms, and the released PTX from the nano-assembly by intracellular esterase effectively induces the apoptosis of cancer cells, which demonstrates a long-term antitumor effect in vivo. This novel strategy may provide future directions for designing an effective anticancer drug delivery system with enhanced stability in the circulatory system, tumor-targeted delivery, and intracellular drug release. |
