| 학회 | 한국화학공학회 |
| 학술대회 | 2003년 가을 (10/24 ~ 10/25, 한양대학교) |
| 권호 | 9권 2호, p.1568 |
| 발표분야 | 고분자 |
| 제목 | Bioactive biomaterials using drugs and cells |
| 초록 | In the authors' laboratory, various approaches to improved biocompatibility of bioactive materials have been studied. In this paper, synthetic polymers and biological tissues having heparin (Hep) or L-arginine (Arg) will be discussed in detail. These synthetic polymers and heparin or L-arginine containing materials have provided for interesting bioactive interactions with blood, cell, and tissue. As synthetic materials, a novel Hep-conjugated biodegradable polymer [polylactide (PLA)-Hep] and a novel injectable thermosensitive polymer [copolymer of chitosan and N-isopropylacrylamide (NIPAAm)] were prepared as candidates for blood/tissue compatible material and drug carrier. In addition, as biological tissues having bioactive agents, cellular/acellular matrices (BP/ABP) of bovine pericardium (BP) were chemically modified by the direct coupling of Arg or Hep after glutaraldehyde (GA) cross-linking. The biocompatibility of these synthetic polymers and modified biological tissues was evaluated in vitro and in vivo. |
| 저자 | 박기동, 김효주, 배진우, 지경수, 박형달 |
| 소속 | 아주대 |
| 키워드 | bioactive biomaterials |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
