| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
3D vascular construction using engineered perfusable microfluidic devices |
| 초록 |
Vascularization in three-dimensional (3D) environments is one of the crucial factors to be overcome in tissue engineering fields. Since cells are always placed at three-dimensional environments in living organisms, Optimization of vascularization in 3D environments has been attempted for many years. However, constructing cells and tissues over 500 um in thickness is pretty challenging due to lack of effective delivery of nutrient and oxygen to all tissue regions. Herein, we constructed a perfusable channeled device to fulfill the vascularized 3D tissue structure. The microfluidic device contains three perfusable channels (500 ㎛ diameter). We seeded human umbilical vein endothelial cells (HUVECs) in the channel, and the cells were fully proliferated to form endothelial monolayer in channel wall (~ 500 cells/㎟) with ≥70 % of cell viability for 2 weeks. Our perfusable vascular bed can be potentially used in large-size tissue regeneration as well as drug screening study. |
| 저자 |
송보아, 정홍수, 김현령, 박민희, 윤다영, 전호정, 이강원
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| 소속 |
한국과학기술(연) |
| 키워드 |
vascular; microfluidic device; 3D
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| E-Mail |
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