| 초록 |
Graft-through technology is emerging in the development of blood-contacting medical devices such as intravenous catheter. To improve their resistance to infection and thrombosis, the technology was studied and applied to develop a catheter prototype, peripherally inserted central venous catheter (PICC). Grafting condition of zwitterionic monomers, such as SBMA, CBMA, MPC, on the catheter surface that previously compounded with biofunctional oligomeric additives was investigated. Optimized conditions are applied to the prototype of PICC and evaluated in aspects with therapeutic efficacy and biological safety. The prototype underwent water contact angle measurement, lubricant test, plasma protein adsorption test, thrombus accumulation with blood loop apparatus, bacterial adhesion assay, cytotoxicity test and in vivo intravenous insertion in Canine model. These results will be employed to commercialize the PICC and utilized to expand to various blood-contacting medical devices. |
