| 학회 |
한국재료학회 |
| 학술대회 |
2018년 가을 (11/07 ~ 11/09, 여수 디오션리조트) |
| 권호 |
24권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Efficient self-assembled microRNA delivery system consisting of cholesterol-conjugated microRNA and PEGylated polycationic polymer for tumor treatment |
| 초록 |
MicroRNA (miR), a key molecule involved in endogenous RNA interference, is a promising therapeutic agent. In vivo delivery of miR, however, is a major factor limiting its application because its polyanionic nature and vulnerability to breakdown make delivery of miR to targeted lesions difficult. To overcome these challenges, we developed a self-assembled miR delivery system consisting of cholesterol-conjugated miR and polyethylene glycol-grafted polyethylene imine. Nanosized complexes of miR with polyethylene imine, which protected miR and its delivery into targeted lesions in vivo, were successfully synthesized by polyethylene glycol grafting. The hydrophobicity of cholesterol improved the structural stability of the complex, preventing the loss of miR. Here, we report the preparation of this self-assembled complex. We examined the delivery efficiency and validated the therapeutic efficacy of the complex. In conclusion, our miR delivery system shows considerable potential for effective in vivo delivery of miR. |
| 저자 |
Byeonggeol Mun1, Eunji Jang2, Seungmin Han3, Hye Young Son4, Yuna Choi5, Yong-Min Huh6, Seungjoo Haam7
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| 소속 |
1Department of Chemical and Biomolecular Engineering, 2College of Engineering, 3Yonsei Univ., 4MediBio-Informatics Research Center, 5Novomics Co. Ltd., 6Seoul, 7Korea |
| 키워드 |
Self-assembled miRNA delivery; RNA interference; Cholesterol conjugation; polycationic polymer; cancer therapy
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| E-Mail |
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