| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | 3D-Nanostructured TiO2 on Conducting Substrate for Enhanced Trans-differentiation of Human Hepatic Progenitors into Insulin Producing Cells |
| 초록 | Here we report a new strategy for enhanced in vitro trans-differentiation of human-hepatic-progenitor-cells (hHPCs) into insulin-producing-cells (InPCs) on biologically-compatible micro-chips of 3D-nanostructured TiO2, grown on conducting substrates (CS). The physiological function of trans-differentiated hHPCs confirmed highly enhanced activation of intracellular Ca++ signaling and induced activation of pancreatic transcription factors during trans-differentiation process under hyperglycemic challenge which triggers the insulin exocytosis. The InPCs on nano-TiO2 chips showed upregulated expression of master regulator Pdx-1, β-cell specific marker Nkx-6.1 and more importantly C-peptide similar to human pancreatic β-cells during hyperglycemic challenge. Acknowledgement This research was supported by the National Research Foundation of Korea (NRF) and grant funded by the Korea government (MSIP) (No. 2017R1A2B1012074). |
| 저자 | 박경희 |
| 소속 | 전남대 |
| 키워드 | TiO2; Insulin Producing Cells; Conducting Substrate; Human Hepatic Progenitors |
