| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Polymersome-amplified fluorescence immunoassay (PAFIA): Fluorescence detection platform of Alzheimer's disesase |
| 초록 |
Alzheimer's disease (AD) is the most common degenerative brain disease, with symptoms impaired cognitive function in the early stages as the disease progresses. We designed an immunosensor to diagnose AD using tear fluid. The platform targets apolipoprotein E (Apo E) is specifically found in tears from AD patients. We using inorganic and organic nanoparticles, can detect biomarkers Apo E, by fluorescent signal. As inorganic nanoparticles, magnitic nanoparticles (MNP) with superparamagnetic property can separate and concentrate the biomarkers. Psomes as organic nanoparticles, are polymeric nanoparticles synthesized using amphiphilic polymers. Since the fluorescent dyes are loaded in the psome's membrane, the amplified fluorescent signal can be expressed in the presence of biomarkers. The immunosenor, consists of magnetic nanoparticles (MNP) and polymersomes (Psomes), has a detection time of less than 1.5 hours and an LOD value of 1 fmol/ml, enabling early diagnosis of AD. |
| 저자 |
이소정, 임종우, 박채원, 박근선, 기지선, 신무광, 함승주
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| 소속 |
연세대 |
| 키워드 |
Alzheimer's disesase; Magnetic nanoparticles; Polymer nanoprobes; Immunoassay; Tear fluids
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| E-Mail |
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