화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터)
권호 44권 2호
발표분야 고분자합성
제목 Synthesis of an Information-Storing Monodisperse Copolyester Composed of an Absolutely Defined Aperiodic Sequence
초록 Unlike DNAs and proteins, synthetic polymer involves statistical uncertainties in terms of the number and sequence of monomers. The scalable synthesis of a polymer composed of an absolutely defined aperiodic sequence remains a long-standing challenge in polymer science. Here, we report the copolymers of α-hydroxy acids, poly(phenyllactic-co-lactic acid) (PcL) built via the cross-convergent method. Overcoming the limitations of the solid-phase synthesis of sequence-defined oligomers and polymers, our proposed method allows scalable synthesis of sequence-defined PcL in a minimal number of coupling steps from reagents in stoichiometric amounts. Digital information, 64-bit word (SEQUENCE), can be stored in an aperiodic sequence of PcL without errors, and this can be fully retrieved as binary code by tandem mass spectroscopy. Our results could enable the exploration of new properties and functions arising from the unlimited diversity of their chemical structures.
저자 이정민, 김경택
소속 서울대
키워드 정보저장 고분자; 단일분자량 고분자
E-Mail ktkim72@snu.ac.kr