| 초록 |
Polylactide and polycarbonate, FDA-approved synthetic polymers, have been extensively used in the biomedical field owing to their favorable biodegradability. However, the lack of hydrophilicity and functionality has limited the biomedical applicability. To address this issue, functional polylactide and polycarbonate have been developed in our laboratory. Utilizing a ring-opening polymerization (ROP) procedure, functional polylactide polymers such as charged polylactides, drug-conjugated polylactides and inorganic carbon dot/polylactide hybrids have been synthesized in advance, followed by converting them into different particulate objects, including nanoparticles, micelles and nanocapsules. Moreover, due to the functionality, cross-linkages, stimuli-responsiveness and targeting ability can be endowed into these particulate objects. This further enhances their biomedical applicability. In addition to polylactide, CO2-based alicyclic polycarbonates have been prepared via dinuclear nickel nitrophenolate-based catalysis, followed by a chemical modification treatment on the resulting polymer for creating a hydrophilic polycarbonate polymer. Due to the improved water solubility, the hydrophilic polycarbonate polymer thus is able to be used in drug and gene delivery applications. |
